2025 NFL Week 2 betting - Monday Night Football: Buccaneers-Texans and Chargers-Raiders - ESPN

The NFL's Week 2 slate wraps up with a «Monday Night Football» doubleheader. The Tampa Bay Buccaneers visit the Houston Texans (-2.5, 42.5) to get things started (7 p.m. ET on ABC/ESPN), followed by the Las Vegas Raiders hosting the Los Angeles Chargers (-3.5, 46.5) in the nightcap (10 p.m. ET on ESPN).

From odds and trends to picks, props and analysis from our experts, here's everything you need to help make your decisions at the betting window.

Note: Odds at time of publication. For the latest updates, visit ESPN BET.

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TB-HOU: Game picks
Prop bets | Betting trends
LAC-LV: Game picks
Prop bets | Betting trends

The Buccaneers went on the road and got a big performance from rookie wide receiver Emeka Egbuka in a 23-20 win over the Atlanta Falcons in Week 1, while the Texans couldn't get anything going in a 14-9 road loss to the Matthew Stafford and the Los Angeles Rams.

The Buccaneers are the odds-on favorite to win the NFC South at -200, while the Texans now find themselves co-favorites with the Jacksonville Jaguars at +185 in the AFC South.

Houston is a 2.5-point favorite in the second game of Monday night's doubleheader.

Tampa Bay Buccaneers at Houston Texans

Maldonado: This is on the premise that Houston doesn't get its act together fast. The Texans were stuck in neutral in Week 1 — bottom three in success rate and a league-worst third-down rate (22%) — and played way too much 11 personnel behind a shaky offensive line. If adjustments aren't made, C.J. Stroud could be in for another long night. Tampa's defense just held Atlanta to 2.5 yards per carry and made Michael Penix Jr. settle for a quick-passing game script. With Vita Vea clogging lanes and Haason Reddick screaming off the edge, Nick Chubb isn't