2025 NFL Week 1 Picks: Best Bets for Every Game — Will's Wagers

Wise weekly wagers … what would an NFL bettor want worse? 

Alliteration aside, the NFL season is just about underway, meaning bettors across the nation are ready to dole out some cash on a weekly basis. 

That's where I come in. 

Each week, I will deliver my favorite bet from each and every game on the NFL schedule.

Welcome to Will's Wagers. 

(All times ET)

THURSDAY, SEPT. 4

COWBOYS @ EAGLES (8:20 p.m., NBC)

George Pickens Over 55.5 receiving yards

The talented-but-temperamental wide receiver will go from subpar quarterback play with the Steelers to a more pass-friendly offense with Dak Prescott. He’ll also be in an offense that has CeeDee Lamb to take much of the defensive attention away from him. In a game where Dallas is an 8.5-point underdog, it'll likely throw a lot to catch up, which bolsters receiving stats.

FRIDAY, SEPT. 5

CHIEFS @ CHARGERS (8:15 p.m., YouTube)

Over 45.5 points 

This game will be played in Brazil, and last year’s Brazil matchup saw the Packers and Eagles combine for 63 points, in a game in which both defenses struggled to maintain their footing and both offenses dominated. I expect the Chiefs to put a renewed emphasis on big offensive plays, something they struggled with over the past few seasons. With premier quarterbacks squaring off, I expect these teams to fly Over the point total of 45.5.

SUNDAY, SEPT. 7

GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)

Giants +6.5

The Commanders swept the season series against the Giants last year, but won both games by just a combined eight points. The 12 wins by the Commanders were impressive, but included a lot of good fortune in close games against a shaky group of opposing quarterbacks. I like the Giants to keep this one close.

BENGALS