2025 Indy 500 predictions: Pato O'Ward best bet to win, Kyle Kirkwood to show

The Indianapolis 500 this year will feature two drivers in particular whose storylines are all about chasing history. 

Josef Newgarden is attempting to win his third consecutive Indy 500. No one in the 108-year history of the race has won back-to-back-to-back.

Helio Castroneves is attempting to win for the fifth time. No one in the 108-year history of the race has won five.

Will either accomplish that feat?

Both have long roads. Newgarden starts 32nd in the 33-car field after a technical infraction last Sunday sent him to the rear. Castroneves starts 22nd and hasn’t been happy with his car in practice.

With that in mind, here are some of my predictions.

Pato O’Ward Outright Winner

O’Ward has finished second in two of the last three Indy 500s, and he crashed while battling for second late in the race in 2023. The Arrow McLaren driver has his best starting spot of third. This pick might be a little bit more from the heart than the head. Yes, I know that can be dangerous. But sometimes you just have that feeling. What’s the saying? You have to lose one before you win one. Some would say he’s lost three.

PICK: Pato O'Ward (+500) to win Indy 500

Alex Palou Outright Winner 

Yes, I'm backing Palou as another potential first-time winner. And no, he's never won on an oval. But considering he has won four of the first five races this year and starts on the outside of Row 2, he is in position to stay out front. He and the Ganassi team have executed flawlessly this year, and that is what this race takes. And he’s been extremely fast in practice.

PICK: Alex Palou (+600) to win Indy 500

Scott McLaughlin Place

McLaughlin has a backup car, but it’s a new ride that was purposely built for a speedway. He starts 10th and even