2025 CFP First-Round Odds: Lines, Spreads for Each Opening Game

Now that the College Football Playoff bracket is set, bettors are looking ahead to the odds for the first round of games.

Notably, Ole Miss and Oregon open as massive, double-digit favorites over Tulane and James Madison, respectively. 

The Bama-OU and Miami-Texas A&M matchups, according to the odds, could yield more competitive results.

Let's look at the odds at DraftKings Sportsbook as of Dec. 11.

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FRIDAY, DEC. 19

No. 9 Alabama @ No. 8 Oklahoma (8 p.m. ET, ABC)

Spread: Alabama -1.5
Moneyline: Alabama -112, Oklahoma -108
O/U: 40.5 

What to know: These two teams faced off during the regular season, back on Nov. 15. In that game, the Sooners traveled to Alabama and beat the Tide, 23-21. Most notably, OU quarterback John Mateer had arguably his most ho-hum game of the season, completing 15 of 23 passes for 138 yards and no passing TDs, although he did rush one in. In addition, Alabama led 10-0 in the first quarter and 17-7 in the second. However, a fumble by Bama QB Ty Simpson late in the third quarter — in Alabama territory — led to an OU field goal to take a 23-21 lead at 13:41 of the fourth quarter, and neither team scored again. Yep, one turnover essentially decided that contest. Oklahoma would go on to close its regular season with wins over Missouri and LSU, while the Tide would beat Eastern Illinois and Auburn in the final two weeks, before falling to Georgia in the SEC title game.

SATURDAY, DEC. 20

No. 10 Miami @ No. 7 Texas A&M (noon ET, ABC)

Spread: Texas A&M -3.5
Moneyline: Texas A&M -180, Miami +150
O/U: 51.5 

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