2024 NFL Week 2 odds, lines, spreads for all 16 games

And just like that, Week 1 of the NFL season is nearly in the books — we've still got a huge Monday night showdown between the Jets and 49ers. 

After that, we're on to Week 2. 

Let's check out the lines for each NFL game at DraftKings Sportsbook, as the second week of the season is upon us. 

(All times ET)

THURSDAY, SEPT. 12

BUFFALO BILLS @ MIAMI DOLPHINS (8:15 p.m., Prime Video)

Point spread: Dolphins -1 (Dolphins favored to win by one point or more, otherwise Bills cover)
Moneyline: Dolphins -118 favorites to win(bet $10 to win $18.47 total); Bills -102 underdogs to win (bet $10 to win $19.80 total)
Total scoring Over/Under: 51 points scored by both teams combined

SUNDAY, SEPT. 15

NEW ORLEANS SAINTS @ DALLAS COWBOYS (1 p.m., FOX and FOX Sports app)

Point spread: Cowboys -6.5 (Cowboys favored to win by 7 points or more, otherwise Saints cover)
Moneyline: Cowboys -290 favorites to win(bet $10 to win $13.45 total); Saints +235 underdogs to win (bet $10 to win $33.50 total)
Total scoring Over/Under: 45.5 points scored by both teams combined

TAMPA BAY BUCCANEERS @ DETROIT LIONS (1 p.m., FOX and FOX Sports app)

Point spread: Lions -6.5 (Lions favored to win by 7 points or more, otherwise Buccaneers cover)
Moneyline: Lions -330 favorites to win(bet $10 to win $13.03 total); Buccaneers +265 underdogs to win (bet $10 to win $36.50 total)
Total scoring Over/Under: 49.5 points scored by both teams combined

INDIANAPOLIS COLTS @ GREEN BAY PACKERS (1 p.m., FOX and FOX Sports app)

Point spread: Colts -3 (Colts favored to win by 3 points or more, otherwise Packers cover)
Moneyline: Colts -155 favorites to win(bet $10 to win $16.45 total); Packers +130 underdogs to win (bet $10 to win $23 total)
Total scoring