2024 NFL Week 2: Betting odds and lines for every game - ESPN

Week 2 of the NFL schedule kicked off Thursday with an AFC East matchup between the underdog Buffalo Bills who upset slight favorites Miami Dolphins 31-10. It will conclude on Monday Night Football when Jalen Hurts and the Philadelphia Eagles play their home — and North American — opener against the Atlanta Falcons.

The Las Vegas Raiders opened as the biggest underdogs of the week and that line has continued to move their road date with the Baltimore Ravens, while the biggest total on the slate belongs to the Tampa Bay Buccaneers and Detroit Lions for their Sunday afternoon game in Detroit. C.J. Stroud and the Houston Texans are giving up 6.5 points to Caleb Williams and the Chicago Bears for Sunday's night game.

Here's a look at all the Week 2 games. Football Power Index (FPI) by ESPN Sports Analytics. Odds current as of publication time. For most current odds go to ESPN BET

San Francisco 49ers -5 vs. Minnesota Vikings
Sunday 1:00 PM ET, CBS

Money Line: 49ers (-230); Vikings (+195)
Total: 46.5; Opened: 46.5
FPI favorite: 49ers by 5

Los Angeles Chargers -5 vs. Carolina Panthers
Sunday 1:00 PM ET, CBS

Line movement: opened Chargers -3

Money Line: Chargers (-230); Panthers (+195)
Total: 39.5; Opened: 42
FPI favorite: Chargers by 7

Indianapolis Colts -2.5 vs. Green Bay Packers
Sunday 1:00 PM ET, FOX

Money Line: Colts (-150); Packers (+130)
Total: 40.5; Opened: 47.5
FPI favorite: Colts by 1.8

New York Giants vs. Washington Commanders -1.5
Sunday 1:00 PM ET, FOX

Money Line: Giants (+105); Commanders (-125)
Total: 43.5; Opened: 42.5
FPI favorite: Commanders by 4.3

New Orleans Saints vs. Dallas Cowboys -6
Sunday 1:00 PM ET, FOX

Money Line: Saints (+220); Cowboys (-270)
Total: 46.5; Opened: 44.5
FPI favorite: Cowboys by 4.2

Cleveland Browns