2024 NFL Week 15 betting - Los Angeles Rams at San Francisco 49ers picks, odds, lines - ESPN

Week 15 of the NFL season gets underway with a matchup between NFC West rivals on «Thursday Night Football.»

The 7-6 Los Angeles Rams (+175 to win the division, +155 to make the playoffs) will visit the 6-7 San Francisco 49ers (18-1, 8-1), with both teams trying to chase down the first-place Seattle Seahawks, who sit at 8-5. In Week 3, the Rams rallied from a double-digit deficit to stun the 49ers, 27-24.

The Rams have won two straight and are coming off a wild 44-42 victory over the Buffalo Bills in Week 14. The injury-riddled 49ers had dropped three in a row before dismantling the Chicago Bears 38-13 last week.

Action from Levi's Stadium in Santa Clara gets going at 8:15 p.m. ET on Prime Video.

Odds current as of publish time, courtesy of ESPN BET

Spread: 49ers -3 (Opened 49ers -2.5)
Moneyline: 49ers -145, Rams +125
Over/Under: 49.5 (Opened 48.5)

First-half spread: 49ers -1.5 (-105), Rams +1.5 (-115)
49ers total points: 25.5 (Over -110/Under -120)
Rams total points: 23.5 (Over -105/Under -125)

Matchup predictor (according to ESPN Analytics): 49ers 60.8% chance to win

Matthew Stafford total passing yards: 249.5 (Over +100/Under -130)
Stafford total passing TDs: 1.5 (Over -135/Under +105)
Brock Purdy total passing yards: 249.5 (Over -135/Under +105)
Purdy total passing TDs: 1.5 (Over -155/Under +120)

Kyren Williams total rushing yards: 70+ (Over -135)
Brock Purdy total rushing yards: 20+ (Over -130)

Puka Nacua total receiving yards: 89.5 (Over -125/Under -105)
Cooper Kupp total receiving yards: 69.5 (Over +105/Under -135)
Jauan Jennings total receiving yards: 69.5 (Over -115/Under -115)
George Kittle total receiving yards: 59.5 (Over -115/Under -115)
Deebo Samuel Sr. total receiving yards: 49.5 (Over -110/Under -115)

Tyler Fulghum