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Round 15 of the United Rugby Championship season kicks off with two games on Friday as the Sharks host the Dragons before Glasgow Warriors face Zebre Parma.
Wales take on Italy as they bid to finish third in the 2022 Six Nations table.
Alun Wyn Jones starts his first rugby game in five months when Wales host Italy in their Six Nations finale on Saturday.
Dan Biggar and Alun Wyn Jones will both achieve major milestones in Wales' Six Nations clash against Italy on Saturday.
Wayne Pivac has brought Alun Wyn Jones back into the starting XV against Italy this weekend, as he makes seven changes to the side that lost narrowly to France.
It was hard not to feel a pang of sympathy for every Wales player on duty against France in the Six Nations last Friday evening.
Wales face a Grand Slam-chasing France tonight at the Principality Stadium, coming up against the team who ended their own clean sweep chances at the 11th hour in the last Six Nations.
Wales will seek to end France's bid for a first Six Nations Grand Slam since 2010 when the sides meet at the Principality Stadium on Friday.