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Tadhg Furlong, Cian Healy and Jamison Gibson-Park will all miss Ireland's crunch Six Nations game with France on Saturday but skipper Johnny Sexton is expected to be available.
Leinster make three changes to their pack for Saturday's Heineken Champions Cup tie against Racing 92 at the Aviva Stadium, live on RTÉ2 and RTÉ Player.
Hugo Keenan will make his 50th appearance for Leinster when they face Gloucester at Kingsholm in Saturday's Heineken Champions Cup tie (kick-off 1pm).
The Ospreys will be looking to keep up their recent run of good form when they welcome United Rugby Championship leaders Leinster to Swansea on Saturday evening.
Jack Conan wants to make a statement against the Ospreys on Saturday after growing frustrated by his lack of first-team opportunities with Leinster.
Leinster head coach Leo Cullen says he won't get "bogged down" by the makeup of Gloucester's team for tomorrow night's Champions Cup meeting at the RDS [live on RTÉ2 and RTÉ Player].
Johnny Sexton will make his return from a calf injury for Leinster in tomorrow night's Champions Cup Pool A clash with Gloucester at the RDS (live on RTÉ2 and RTÉ Player), however Tadhg Furlong once again misses out.
Johnny Sexton and Tadhg Furlong will miss Leinster's Heineken Champions Cup opener against Racing 92 due to injury.