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Tadhg Furlong, Jamison Gibson-Park and Robbie Henshaw have been included in Ireland's training squad for this week, while Finlay Bealham has been ruled out for the rest of the Guinness Six Nations.
The best number 8 in the world, many contend, starts today's game out of position.
Ross Byrne and Craig Casey will make their first starts in the Six Nations for Ireland as they make six changes for their clash against Italy.
DUBLIN : Ireland have made six changes for Saturday's Six Nations trip to Italy, with each of those players having come off the bench to see off France last time out in a victory that made the world's top-ranked team championship favourites.
Ross Byrne will make his first Guinness Six Nations start as one of six changes to the Ireland team to take on Italy on Saturday.
DUBLIN : Ireland flyhalf Johnny Sexton will miss the Six Nations leader's trip to Italy this weekend, the Irish Rugby Football Union (IRFU) said on Wednesday, with lock James Ryan named as captain for the game.
Ireland will focus entirely on beating Italy but Jack Conan admits that the tantilising prospect of Ireland winning a Guinness Six Nations title in Dublin bubbles beneath the surface.
Ireland look certain to be without Tadhh Beirne for the Guinness Six Nations clash against Italy in two weeks' time, while a number of other players are on the treatment table.