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Experienced lock Alun Wyn Jones has been left out of the Wales match-day 23 to face Scotland in their Six Nations clash at Murrayfield on Saturday as head coach Warren Gatland says they are "looking to the future".
The Ospreys host arch-rivals the Scarlets in a crucial West Wales derby in Swansea this afternoon.
Wales international Owen Williams will make his first start for the Ospreys as they head to France to take on French champions Montpellier.
Australia came from 34-13 down to beat Wales 39-34 in an extraordinary Autumn Nations Series Test at The Principality Stadium on Saturday which will pile the pressure on home coach Wayne Pivac.
Scarlets back row Josh Macleod will make his Wales debut after being selected by head coach Wayne Pivac for Saturday's autumn international against Georgia in Cardiff.
The Ospreys welcome the Stormers to Swansea this evening as they look to launch a charge up the table.
A much-changed Ospreys side head to Northern Ireland this evening to take on Ulster at the Kingspan Stadium.