Under-fire Manchester United boss Erik ten Hag cannot afford another damaging defeat when his troubled side face Fulham on Saturday.
Tottenham's Premier League title challenge will get an intriguing test as the leaders' former boss Mauricio Pochettino returns with Chelsea.
Arsenal also harbour title aspirations, making their showdown with top-four contenders Newcastle one of the weekend's marquee match-ups. Crisis-torn Man Utd have to 'stand up' Erik ten Hag urged his Manchester United flops to "stand up" to the pressure as the Dutch coach battles to stop their season imploding.
United have made their worst start since 1962-63 and a loss against Fulham at Craven Cottage could push Ten Hag to the brink of the sack after less than two seasons in charge.