Sportsmail's guide to this weekend's Premier League action

It is arguably the biggest weekend of the Premier League season, with so many clubs in crucial fixtures that could have a decisive impact on their campaigns.

Leaders Manchester City host second-place Liverpool in a tie that could decide this season's champion. Meanwhile, Frank Lampard is fighting for Everton's Premier League future in a crunch game against Manchester United, who also need to reignite their Champions League ambitions. 

On top of that, Norwich host Burnley in a huge match at the bottom of the table, while Watford versus Leeds could also be relegation battle.

Sportsmail's Lewis Steele gives all the details ahead of the weekend's action, with predicted line-ups, teams news, stats and TV details. 

EVERTON V MANCHESTER UNITED 

Everton: Allan and Michael Keane return to the squad after suspension.

Out: N Patterson (ankle), Y Mina, D Van de Beek, T Davies (all thigh), A Townsend (knee).  

Manchester United: Luke Shaw is still injured after limping off last week, though Cristiano Ronaldo returns.

Out: E Cavani (calf), L Shaw (calf), R Varane, S McTominay (both knock).  

Everton have won just one of their last 13 league games against Manchester United, who won 3-1 at Goodison Park last season. They haven’t won two straight league games there since 2007. United are also winless in their last four 12.30pm kick-offs on a Saturday.

ARSENAL V BRIGHTON  

Arsenal: Huge blow as Kieran Tierney is out for the season, with Thomas Partey also having ‘a significant injury’.

Out: T Partey (thigh), T Tomiyasu (calf), K Tierney (knee).

Brighton: A ‘devastating blow’ saw Jakub Moder ruled out for the season and in a race against time for the World Cup with Poland. 

Out: A Webster (groin), M Caicedo (illness), J Moder (knee). 

Arse