Six Nations 2022: What now for England and injured Manu Tuilagi?

England's Manu Tuilagi hopes to return soon after withdrawing from the side to face Wales on Saturday, says forwards coach Richard Cockerill.

Around eight hours after being named to start for the first time in this Six Nations, Tuilagi was ruled out because of a minor hamstring problem.

The latest twist in the centre's injury-hit career means England will not announce their starting XV until they arrive at Twickenham on Saturday.

«He's in good spirits», Cockerill said.

Head coach Eddie Jones described the 30-year-old Tuilagi as «unique» after Thursday's team announcement.

Cockerill added: «He's left camp and he's at home. It's not too serious as far as we know. Hopefully he'll be back soon.»

Despite the fact Tuilagi will now have missed 80 Tests since making his debut in 2011, England have often struggled to find a suitable alternative in midfield.

His absence is likely to mean a new gameplan will be required against Wales.

Henry Slade is set to move to inside centre, with Joe Marchant — called back into the squad after Tuilagi's injury — or Elliot Daly available at 13.

Cockerill added: «It's obviously disappointing for the team because he would have been an important member of the squad.»

Previously ready to return from a tear to the same hamstring, Tuilagi's power brought balance alongside the more delicate combination of Marcus Smith and Slade in midfield.

Without him, England have less chance of being direct in attack and could struggle to burst through Wales' defensive line.

Both sides seek victory at Twickenham to keep their Six Nations campaigns on track after losing their opener and former Ireland wing Shane Horgan believes the late change may have lost England the favourites tag.

«I think Eddie [Jones] had one eye on Tuilagi