The Sharks have opted to deploy their host of Springboks into the starting XV for the United Rugby Championship (URC) match against Ulster at Kings Park on Saturday.
Thomas du Toit will captain a side consisting of Ox Nche, Bongi Mbonambi, Siya Kolisi and Makazole Mapimpi, who all played from the bench last weekend in the Sharks' 40-12 win against Glasgow Warriors.
Nche comes in for Ntuthuko Mchunu, while Mbonambi swaps jerseys with Kerron van Vuuren and Siya Kolisi takes over from Dylan Richardson among the changes in the forwards.
In the backline, Mapimpi replaces Anthony Volmink in the final change to last week's starting line-up.
Jaden Hendrikse and Boeta Chamberlain will continue as the halfback pair.
Kick-off is at 16:05 on Saturday.
Sharks team:
15 Aphelele Fassi, 14 Werner Kok, 13 Marnus Potgieter, 12 Ben Tapuai, 11 Makazole Mapimpi, 10 Boeta Chamberlain, 9 Jaden Hendrikse, 8 Phepsi Buthelezi, 7 Vincent Tshituka, 6 Siya Kolisi, 5 Hyron Andrews, 4 Eben Etzebeth, 3 Thomas du Toit (captain), 2 Bongi Mbonambi, 1 Ox Nche
Substitutes: 16 Kerron van Vuuren, 17 Ntuthuko Mchunu, 18 Carlu Sadie, 19 Reniel Hugo, 20 James Venter, 21 Sikhumbuzo Notshe, 22 Cameron Wright, 23 Anthony Volmink
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