Serena Williams opens up about 31-pound weight loss using GLP-1 medication: ‘Something I suffered with’

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Tennis great Serena Williams has opened up about her weight loss journey, revealing she lost 31 pounds with the help of a GLP-1 medication. 

The 23-time Grand Slam champion revealed in interviews with People magazine and "Today" that she turned to a GLP-1 medication after struggling with her health after the birth of her second daughter.  

In this Sept. 7, 2019, file photo, Serena Williams returns a shot to Bianca Andreescu of Canada during the women's singles final of the U.S. Open tennis championships in New York.  (AP Photo/Eduardo Munoz Alvarez, File)

"In particular, after having my second kid, I was never able to be at a healthy weight that I could be at, whether it was my joints or blood sugar levels. It was just always something I suffered with, and a lot of women actually go through this," Williams said during an appearance on "Today" Thursday. 

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Williams, 43, said despite being a trained athlete, she struggled to lose weight regardless of how active she was. She said it began to take a toll on her joints. 

"No matter what I did — Running, walking. I would walk for hours because they say that's good. I literally was playing a professional sport — and I could never go back to where I needed to be for my health. Then, after my second kid, it just even got harder. So then I was like, ‘OK, I have to try something different.’"

Williams said she decided to be open about her journey to destigmatize the use of GLP-1 medication for weight loss.  

Serena Williams Aug. 21, 2025, in New York City.   (XNY/Star Max/GC Images)

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