Rams vs. Panthers Prediction, Odds, Picks for NFL Wild Card Round

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports .

The Los Angeles Rams and Carolina Panthers will match up in this year's NFC Playoffs. The Rams are heavy favorites (-10.5). The matchup has an over/under of 46.5 points.

Keep up with the 2025 NFL season on FOX Sports.

The Rams are set up for a decisive win over the Panthers on January 10. With Matthew Stafford at quarterback, Los Angeles has a clear edge in both firepower and experience. The Rams offense has been one of the league’s most productive all season, averaging 30.5 points, the highest mark in the NFL, and leading the league in passing yards with 4,557.

Carolina heads into this matchup after an 8-9 finish and has struggled to find consistency on offense. The Panthers averaged only 18.3 points, ranking 27th in the league. Bryce Young threw for 3,011 yards with 23 touchdowns, but that production is unlikely to be enough against a Rams team that can score quickly and consistently.

Los Angeles is a heavy favorite at -10.5, and Matthew Stafford is the current favorite to control this game from start to finish thanks to his postseason résumé and the Rams pass rush. The Panthers are the underdog in this spot, and it would take a near-perfect performance to flip the script. All signs point to the Rams taking care of business and advancing with authority.

Prediction provided by  FOX Sports' Sports AI .  Download the FOX Sports App for free access to Sports AI.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX