Predicting NFL Week 1 upsets, fantasy football starts and sits, plus buzz and notes around the league

The interminable wait is over, and Week 1 of the 2022 NFL season is finally upon us. An end to all the prognostication and preseason analysis, and time for some actual football. Well… perhaps just a little bit more prognostication and preseason analysis, now that we mention it.

Insiders Dan Graziano and Jeremy Fowler have been keeping you informed on all the latest National Football League happenings since the final second ticked off the Super Bowl LVI scoreboard at SoFi Stadium seven months ago, and will now apply their powers of NFL pulse-checking to the Week 1 schedule.

What are the top upset picks for Week 1? Which players will Graziano and Fowler be watching most closely — both fantasy football-wise and otherwise? Which coaches will begin the 2022 season under the most scrutiny? Who are the new faces in new places who hold the highest level of intrigue? What's the latest buzz from around the league? ESPN's Insiders empty their notebooks and answer all of the biggest questions as another thrilling NFL season gets set to commence with this week's 16-game slate.

Jump to:Upsets | QB debuts | Coaches under pressureNon-QB newcomers | Fantasy start/sitBold 2022 prediction | Everything we're hearing

Graziano: Jaguars (+2.5) over Commanders. I went through my picks and dang, they're chalky this week. This is literally the only upset I picked. But I do like the Jaguars as a little bit of a sleeper team this year. No team in the league underwent a more significant upgrade at the head coaching position, from the all-encompassing disaster of Urban Meyer to the Super Bowl-winning Doug Pederson. I think Trevor Lawrence reminds everybody why he was the first pick.

Fowler: Patriots (+3.5) over Dolphins. Time to put the chalk down,