Ohio State vs. Indiana Prediction, Odds, Picks for 2025 Big Ten Championship

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In this season's Big Ten Championship Game the Ohio State Buckeyes are the favorites, but by less than a touchdown (-4) over the Indiana Hoosiers. Lucas Oil Stadium will host the matchup on December 6, 2025, starting at 8 p.m. ET on FOX. An over/under of 47.5 is set for the contest.

The Buckeyes' last contest was against the Michigan Wolverines, and they won by a score of 27-9. Last time out, the Hoosiers defeated the Purdue Boilermakers, with 56-3 being the final score.

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Take Ohio State over Indiana today in the Big Ten Championship game. The Buckeyes, with their talent and depth, have a strong chance to control this matchup. Ohio State has dominated all season by scoring 37 points per game and allowing only 7.8.

Indiana has been impressive with an offense putting up 44.3 points per game, but Ohio State’s defense matches up well against the Hoosiers’ run-heavy approach. The Buckeyes’ front seven is physical enough to clog rushing lanes, and their secondary stays tight in coverage, which limits explosive plays.

Julian Sayin has delivered all year with 3,065 passing yards and 30 touchdowns. Bo Jackson continues to anchor the ground game with 952 rushing yards.

I expect Ohio State to win by 7 with a projected final score of 24-17. The Over/Under is 47.5, and a lower-scoring game feels likely with both defenses capable of controlling long stretches.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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