NFL Week 6 betting odds, picks, tips -- Who to take in Chiefs-Bills and more

Week 6 of the 2022 NFL season is the first of the year with teams on byes (Detroit, Tennessee, Las Vegas, Houston), but there are still plenty games to keep an eye on, including the night matchup between the Dallas Cowboys and Philadelphia Eagles.

But what does this all mean from a betting perspective? And what are the best plays to help you make smart wagering decisions?

Betting analysts Doug Kezirian, Tyler Fulghum, Joe Fortenbaugh, Anita Marks and Erin Dolan, fantasy and sports betting analysts Eric Moody and Andre Snellings, ESPN Stats & Information's Seth Walder and Football Outsiders' Aaron Schatz offer their insight into the games with tips and picks.

Note: Lines from Caesars Sportsbook unless otherwise indicated.

Doug Kezirian: On a macro level, I would say it's how many backup quarterbacks we have seen and how we handicap those games. Some, such as Cooper Rush, have shined. Others have looked very bad. Oddsmakers and the betting market are kind of lost with how to assess power ratings with these backup quarterbacks.

Joe Fortenbaugh: Teams traveling back from London. There have been seven instances in which a team played in London and then immediately in America the next week without going on a bye. In those seven instances, the opponent of the London team has gone over their team total six times. We saw it happen twice last week with the Bears eclipsing their team total against the Vikings and the Seahawks eclipsing their team total against the Saints (Minnesota and New Orleans had played in London the week prior). As a result, I like the Jets to go over 18.5 points against the Packers and the Ravens to go over 25.5 points against the Giants, as Green Bay and New York faced each other last week across the pond.