NFL divisional round betting: Count on run game to lead Seahawks past 49ers - ESPN

The San Francisco 49ers travel to Seattle for Saturday night's NFC divisional tilt with the Seahawks, and we have the head-to-head tape from the Week 18 game in San Francisco to study.

Matt Bowen will focus on the matchups and look for answers on both clubs and offer his take, and Liz Loza, Pamela Maldonado, Eric Moody, Ben Solak and Seth Walder share their best bets, analysis and DFS plays to help you get in on the action.

Note: Odds provided by DraftKings Sportsbook and subject to change.

Bowen: Kyle Shanahan's run game with Christian McCaffrey has lacked efficiency this season, but it remains the offensive foundation in San Francisco. McCaffrey will see volume Saturday night while also using his elite dual-threat ability as a receiver. In the Week 18 matchup, Seattle limited the 49ers and Brock Purdy to only one completion of 20-or-more yards, and with George Kittle now out with a torn Achilles, Shanahan needs to play the defensive tendencies of Seattle to generate throwing windows.

Edge: Seahawks

Best bet: Jauan Jennings OVER 40.5 receiving yards (-114): Jennings can work the underneath levels versus the Seahawks' two-deep zone coverages, plus Shanahan can set him up on middle-of-the-field targets off play-action, which leads to numbers after the catch. Jennings has had 40-or-more yards receiving in two of his last four games.

Bowen: The run game under Seahawks offensive coordinator Klint Kubiak found daylight on zone-run concepts versus the 49ers in Week 18, as both Kenneth Walker III and Zach Charbonnet rushed for over 70 yards. Look for Seattle to feature the run game on early downs in this matchup, and we know wide receiver Jaxon Smith-Njigba will get his targets from both boundary and slot alignments. And don't