March Madness 2022: Fran Fraschilla's must-watch Sweet 16 matchups, Final Four predictions

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March Madness fans are gearing up to watch college basketball's finest as this week’s Sweet 16 matchups kick off on Thursday night, with last year’s runner-up, Gonzaga, taking on the Arkansas Razorbacks.

With eight games to watch, legendary college basketball coach and analyst Fran Fraschilla predicts what games fans just can’t miss. 

Fraschilla, who coached the Manhattan Jaspers to two NCAA and two NIT appearances from 1992-96 and then led the 1998 St. John’s Red Storm to its first NCAA Championship in five years, spoke with Fox News Digital about his Final Four predictions and his must-watch matchup for this weekend.  

SAINT PETER’S CAPTIVATES THE NATION IN UNLIKELY MARCH MADNESS RUN, FRAN FRASCHILLA SAYS 

"Houston vs. Arizona is a great story because Houston went to the Final Four last year, lost their top seven scorers, including their two leading scorers this season, who were injured during the same week in December and are out for the year," Fraschilla said of the Thursday night matchup. 

Taze Moore of the Houston Cougars reacts after drawing a foul during the game against the Illinois Fighting Illini during the second round of the 2022 NCAA Men's Basketball Tournament on March 20, 2022 in Pittsburgh, Pennsylvania.  (Photo by Kirk Irwin/Getty Images)

"To lose your two leading scorers this season and reinvent yourself and all of a sudden be back in the Sweet 16 is remarkable," Fraschilla said, "but it's not remarkable when you think of their coach, Kelvin Sampson, who at 67 is trying to bring two Houston teams to back-to-back Final Fours."

Sophomore guard Tramon Mark underwent season-ending shoulder surgery after sustaining an injury