Man United win to end Van Nistelrooy's interim spell, Ipswich shock Spurs
Third-placed Nottingham Forest's fine run came to an end in a 3-1 home defeat to Newcastle.
Arsenal are aiming to kickstart their faltering title challenge later away at London rivals Chelsea.
Ruben Amorim will be in charge for the first time when United return from the international break.
But Van Nistelrooy was able to hand over the reins with a four-game unbeaten run since stepping up to replace the sacked Erik ten Hag.
Bruno Fernandes marked his 250th United appearance in style by smashing in his fourth goal in four games after a neat interchange of passes with Amad Diallo.
Fernandes' burst into the box also created the second goal as his glancing touch deflected off Leicester defender Victor Kristiansen and in for an own goal.
Diallo's two-goal showing in a 2-0 Europa League win over PAOK on Thursday earned the Ivorian a start over Alejandro Garnacho.
The Argentine, though, came off the bench to show what he is capable of with a stunning strike into the top corner to round off the scoring.
United remain down in 13th but are now just three points off fifth in a congested table.
Ipswich off the mark
Ipswich will play host to Amorim's first match in two weeks and go into that game buoyed by their first win since ending a two-decade wait to return to the top flight.
Spurs were finally made to pay for their slow starts at home as they went behind for the 13th time in 15 Premier League games at the Tottenham Hotspur Stadium in 2024.
Sammie Szmodics took advantage of statuesque Tottenham defending to open the scoring with an overhead kick on 31 minutes.
Liam Delap doubled the visitors' lead in far less spectacular fashion as he lashed in from point-blank range after Radu Dragusin directed a cross towards his own goal.
Spurs had come