Male birth control pill 99% effective in mice could start human trials this year

Scientists in the United States say they have developed a male birth control pill that is 99 per cent effective in mice without causing side effects, and that could begin human trials by the end of this year.

The findings, unveiled at the American Chemical Society's spring meeting, mark a key step in efforts to expand contraceptive options for men and better share the burden of birth control with women.

While there are scores of options for women to control their menstrual cycle, there have been only two effective options available so far in terms of male contraception: condoms or vasectomies.

But condoms are single-use only, and vasectomies aren’t easy to reverse, so researchers have been working on developing a male contraceptive that’s effective, long-lasting and reversible - similar to the birth control pill for women.

“Scientists have been trying for decades to develop an effective male oral contraceptive, but there are still no approved pills on the market,” said Md Abdullah Al Noman, a graduate student who presented the work at the meeting.

Most compounds currently undergoing clinical trials target the male sex hormone testosterone, which could lead to side effects such as weight gain, depression and increased low-density lipoprotein (known as LDL) cholesterol levels.

“We wanted to develop a non-hormonal male contraceptive to avoid these side effects,” said Noman, who works in the lab of Professor Gunda Georg at the University of Minnesota.

To develop a non-hormonal drug, his team targeted a protein called retinoic acid receptor (RAR) alpha.

Inside the body, vitamin A is converted into different forms, including retinoic acid, which plays important roles in cell growth, sperm formation, and embryo development.

Retinoic