It will be a historic night for Irish football, with teams in group stage action in the Conference League.
Shelbourne take on Swedish side Hacken, while Shamrock Rovers travel to face Sparta Prague.
While Shamrock Rovers have reached group stage football for three out of the last four seasons, this marks another incredible chapter in Shelbourne's journey.
After overcoming the odds to win the Airtricity league last season, Joey O'Brien's side battled through qualifying to ensure their European journey continued into the winter.
For Shamrock Rovers, Stephen Bradley's side became the first Irish side not to win the league and qualify for Europe.
In touching distance of regaining their title and in the semi-finals of the FAI Cup, it could be a very special season for Bradley's side.
Ahead of Thursday night's action, here is all you need to know.
Both Shelbourne v Hacken and Sparta Prague v Shamrock Rovers kick off at 8 pm.
Premier Sports One are showing live coverage of Shelbourne's clash, while Premier Sports Two will be where fans can watch live coverage of Shamrock Rovers.
Premier Sports will be showing live coverage of the Europa and Conference league this season.
Shamrock Rovers are in touching distance of the title after they defeated rivals Bohemians last Friday, and could be the champions this weekend.
After a dip from last season's incredible highs, Shelbourne are currently in sixth place, a point behind Drogheda in fourth and have a game in hand. The top four will qualify for European football if Shamrock Rovers win the FAI Cup, or St Patrick's Athletic win the cup and finish in the top three.
Introduced in 2021, the third tier of European club football has 36 teams competing in a league phase.
The top eight go
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