Deion Sanders' Buffaloes fall to USC; Caleb Williams throws for 6 scores

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After a 3-0 start to the season that took over the conversation in the sport, Deion Sanders’ Colorado Buffaloes have now lost two straight after falling to No. 8 USC 48-41 Saturday. 

For the second consecutive week, the Buffaloes defense failed to put up a fight in the first half, heading into halftime down 34-14 after facing a 35-0 deficit against Oregon in Week 4. 

Colorado head coach Deion Sanders heads into the locker room after players warmed up before a game against Southern California Saturday, Sept. 30, 2023, in Boulder, Colo.  (AP Photo/David Zalubowski)

With Colorado's defense missing Travis Hunter and Shilo Sanders, reigning Heisman Trophy winner Caleb Williams of USC completed 30 of 40 passes for 403 yards, six touchdowns and one interception. 

DEION SANDERS, COLORADO ENTER HALFTIME DOWN BIG FOR SECOND CONSECUTIVE WEEK

"Caleb is playing at a high level. Had a couple that we would love back there at the end that we don’t typically make," USC head coach Lincoln Riley said postgame. "The guy continues to perform for this team. So, proud of his progress, and the rest of the team has to keep coming along."

USC’s offense scored touchdowns on five of its first seven possessions in the first half, while Colorado missed a field goal and quarterback Shedeur Sanders threw an interception that USC turned into points. 

The Buffs came out of halftime with renewed energy, cutting the lead to just seven with under two minutes remaining in the fourth quarter. Colorado’s defense was much improved after the half, but Colorado failed to recover an onside kick following the late score, allowing USC to run out the clock. 

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