Brock Purdy throws 5 touchdowns, spoils Philip Rivers' return to Indianapolis in 49ers' win over Colts

Brock Purdy shared his thoughts of the San Francisco 49ers 37-24 win in Week 15 against the Tennessee Titans.

The San Francisco 49ers spoiled 44-year-old Philip Rivers’ home return for the Indianapolis Colts, as quarterback Brock Purdy threw five touchdowns in the 48-27 victory on the road Monday night.

San Francisco knows that if they win their remaining two games, they would be the No. 1 seed in the NFC heading into the playoffs, and its mission accomplished as they move to 11-4.

Meanwhile, the Colts, after starting the year 8-2, remain on their losing streak despite solid play from Rivers except for a crucial moment in the game.

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Christian McCaffrey of the San Francisco 49ers catches a pass for a touchdown during the first quarter against the Indianapolis Colts at Lucas Oil Stadium on Dec. 22, 2025 in Indianapolis, Indiana. (Kevin Sabitus/Getty Images)

The Colts found themselves down 41-27 with the 49ers already in field goal range when one of the few errant passes from Purdy went through Kendrick Bourne’s hands and was intercepted.

It could’ve been a turning point in the game, especially when Rivers found Alec Pierce, who had a monster game with two touchdowns in the first half, for a 33-yard gain to flip the field. But on the next play, Dee Winters jumped a Rivers pass intended for Ty Warren and took it 74 yards to the house — a game-sealing pick-six.

Though they still have the slimmest of playoff hopes, the Colts’ loss means the Jacksonville Jaguars, Buffalo Bills and Los Angeles Chargers all clinched playoff spots in the AFC.

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Rivers was locked in from the start of the game, as