49ers dominate Seahawks in NFC West matchup, but comes at cost of Trey Lance's season

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Jimmy Garoppolo threw a touchdown pass on his first full drive after replacing an injured Trey Lance and ran for another score to help the San Francisco 49ers beat the Seattle Seahawks 27-7 on Sunday.

Lance broke his right ankle on the second drive of the game, a season-ending injury for the 22-year-old who was given the keys to San Francisco's offense this season. He was taken off the field on a cart, his injured ankle in an air cast.

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Jimmy Garoppolo #10 of the San Francisco 49ers reacts after scoring a touchdown against the Seattle Seahawks during the fourth quarter at Levi's Stadium on September 18, 2022 in Santa Clara, California. (Thearon W. Henderson/Getty Images)

That set the stage for Garoppolo to come in and reclaim the job he held for most of the past four seasons as the surprising decision to keep Garoppolo on a reduced contract paid nearly immediate dividends for the Niners.

He completed his first five passes in his first game since last season's NFC title game, including a 38-yard touchdown pass to Ross Dwelley that put San Francisco (1-1) up 13-0.

The Niners mostly coasted from there as the Seahawks (1-1) looked rather flat six days after their emotional, season-opening victory over former quarterback Russell Wilson and the Broncos.

Geno Smith went 24 for 30 for 198 yards and an interception. Seattle also had a trick play near the goal line backfire for another turnover and rushed for only 35 yards on the day.

Lance took over the starting job this season from Garoppolo after being drafted third overall in 2021. San Francisco traded three first-round picks to move up nine spots