49ers’ defense swarms Rams, Deebo Samuel runs rampant in win

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Matthew Stafford couldn’t breathe from San Francisco’s defensive pressure, as the 49ers defeated their NFC West foe, 24-9, on Monday night. 

The key moment of the game was a pick-six thrown by Stafford on an intended screen pass to Cooper Kupp. Talanoa Hufanga read the play like a book, jumped the route, bobbled the ball for a second and bolted his way into the end zone to make it a two-possession game. 

But that wasn’t the only time the Niners’ defense stymied the Rams’ offense. 

Four sacks were collected in the first half, as Stafford had a hard time in his own pocket. The 49ers would finish with seven on the night, with Pro Bowler Nick Bosa and Samson Edukam leading the way with two apiece.

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Defensive end Nick Bosa #97 of the San Francisco 49ers sacks quarterback Matthew Stafford #9 of the Los Angeles Rams during the first quarter at Levi's Stadium on October 03, 2022 in Santa Clara, California. (Ezra Shaw/Getty Images)

On offense, Deebo Samuel led the way with 115 receiving yards that included a 57-yard touchdown catch-and-run in the second quarter. Samuel stayed upright after multiple tackles and used his blazing speed to get across the field and into the end zone for six. 

Jeff Wilson Jr. had the first touchdown of the game, thanks to a perfect hole that opened the way to a 32-yard run for the score. He finished the game with 74 yards on 18 attempts. 

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Kupp was the only threat for the Rams in this one. He had 14 catches, a new career-high, for 122 yards and one touchdown, though that score came at the end of the game