49ers' Christian McCaffrey suffered 'potentially' season-ending knee injury vs Bills, coach says

The Buffalo Bills beat the San Francisco 49ers 35-10 in a game that was dominated by Josh Allen. Craig Carton, Danny Parkins, Mark Schlereth, and Greg Jennings ask if the Bills are the best team in the AFC.

San Francisco 49ers star Christian McCaffrey left Sunday night’s 35-10 loss to the Buffalo Bills with a knee injury, but it appeared to be much worse than that.

McCaffrey is believed to have suffered a posterior cruciate ligament (PCL) injury and could "potentially" see his season come to an end, 49ers head coach Kyle Shanahan said.

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San Francisco 49ers running back Christian McCaffrey, #23, runs against Buffalo Bills safety Taylor Rapp, bottom, during the first half of an NFL football game in Orchard Park, New York, on Sunday, Dec. 1, 2024. (AP Photo/Adrian Kraus)

"I think PCL is usually a couple weeks, but I’m not exactly sure yet," he added.

The running back was a focal point of the 49ers’ game plan early against the Bills. As the snow came down on the field at Highmark Stadium, McCaffrey ran the ball seven times and was targeted three times through the air.

He had 53 rushing yards and two catches for 14 yards before he left the field.

It was a crushing blow to a team that has been riddled with injuries on both sides of the ball. The snow made matters much worse for San Francisco. Brock Purdy had only 94 passing yards on 18 attempts.

"He’s one of the best running backs in the league," Purdy said of McCaffrey. "When you lose him like that, I think it takes away just sort of how we do some things in the offense."

San Francisco 49ers running back Christian McCaffrey, #23, is hit by Buffalo Bills safety Damar Hamlin, #3, during the first half of an NFL football game