May 15, 2026 - 01:03
By espn.com

2026 NFL schedule release: Odds for every Week 1 game, other highlights - ESPN

The complete 2026 NFL schedule has been released, and odds are already available for Week 1 and several other high-profile games.

The Seattle Seahawks and New England Patriots will meet in a Super Bowl rematch in the NFL's season opener on Wednesday, Sept. 9. The defending champion Seahawks opened as 3.5-point home favorites.

The international series gets going Thursday, Sept. 10, with an NFC West matchup between the Los Angeles Rams — the current favorites to win the Super Bowl — and rival San Francisco 49ers in Melbourne, Australia.

The largest spread of Week 1 belongs to the Los Angeles Chargers, who are favored by 11.5 points over the Arizona Cardinals. The Chargers are the only double-digit favorite. Nine games have spreads of a field goal or less.

The highest points total in Week 1 is the Tampa Bay Buccaneers-Cincinnati Bengals matchup (50.5).

Here's a look at the early odds for every Week 1 game, as well as other highlights on the schedule that already have spreads.

Odds by DraftKings Sportsbook and subject to change.

New England Patriots at Seattle Seahawks (-3.5)
8:20 p.m. ET on NBC

Moneyline: Seahawks -192, Patriots +160
Total: 44.5 points

San Francisco 49ers vs. Los Angeles Rams (-2.5)
Melbourne Cricket Ground, Melbourne, Australia
8:35 p.m. ET on Netflix

Moneyline: Rams -148, 49ers +124
Total: 48.5 points

Chicago Bears (-2.5) at Carolina Panthers
1 p.m. ET on FOX

Moneyline: Bears -135, Panthers +114
Total: 44.5 points

Tampa Bay Buccaneers at Cincinnati Bengals (3.5)
1 p.m. ET on FOX

Moneyline: Bengals -198, Buccaneers +164
Total: 50.5 points

Check out all 32 teams' Super Bowl odds, win total projections and more.