2026 Indy 500 Odds: Alex Palou Favored, Kyle Kirkwood Close Second

When Alex Palou takes the track for the 110th Running of the Indianapolis 500, he'll do so as the reigning champion of both INDYCAR and of the Indy 500. 

And based on how the 2026 INDYCAR season is unfolding, Indianapolis could be kind to Palou for the second consecutive year. He's already won three races so far this season and sits atop the points standings. Now he's the favorite to repeat at the "Greatest Spectacle in Racing."

Will he keep his foot on the gas when the series goes to the Brickyard for the Indy 500 on Sunday, May 24 (coverage beginning at 10 a.m. ET on FOX)?

Let's take a look at the odds at DraftKings Sportsbook as of April 27, along with expert insight from FOX Sports Motorsports Insider Bob Pockrass.

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Alex Palou: 9/2 (bet $10 to win $55 total)
Josef Newgarden: 11/2 (bet $10 to win $65 total)
Pato O'Ward: 13/1 (bet $10 to win $75 total)
David Malukas: 8/1 (bet $10 to win $90 total)
Scott McLaughlin: 10/1 (bet $10 to win $110 total)
Kyle Kirkwood: 10/1 (bet $10 to win $110 total)
Christian Rasmussen: 12/1 (bet $10 to win $130 total)
Marcus Ericsson: 14/1 (bet $10 to win $150 total)
Scott Dixon: 15/1 (bet $10 to win $160 total)
Will Power: 16/1 (bet $10 to win $170 total)
Takuma Sato: 18/1 (bet $10 to win $190 total)
Alexander Rossi: 18/1 (bet $10 to win $190 total)
Santino Ferrucci: 20/1 (bet $10 to win $210 total)
Conor Daly: 20/1 (bet $10 to win $210 total)
Ryan Hunter-Reay: 25/1 (bet $10 to win $260 total)
Mick Schumacher: 25/1 (bet $10 to win $260 total)
Helio Castroneves: 25/1 (bet $10 to win $260 total)
Felix Rosenqvist: 25/1 (bet