2025 NFL TNF Week 1 betting - Cowboys-Eagles odds, picks - ESPN

The NFL season begins with a classic NFL East rivalry, as the defending Super Bowl champion Philadelphia Eagles host the Dallas Cowboys on Thursday night.

The Eagles started last season 2-2 but rattled off 10 straight wins following their Week 5 bye and only suffered one more loss the rest of the way en route to their second Super Bowl victory in eight years.

As for the Cowboys, things didn't go quite as planned, especially against the reigning champs. The Eagles swept the season series, outscoring the Cowboys 75-13 in the process. To add injury to insult, Dak Prescott suffered a hamstring injury in Week 9 against another feathered team in Atlanta and missed the rest of the season.

But it's a new season, and everything is relative when it comes to betting. From odds and trends to picks, props and analysis from our experts, here's everything you need to help make your decisions at the betting window.

Note: Odds at time of publication. For the latest updates, visit ESPN BET.

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Dallas Cowboys at Philadelphia Eagles

Matt Bowen: The Eagles averaged 187.3 rushing yards per game in 2024, and I don't see the script changing versus the Cowboys on Thursday night. Behind the league's best offensive line — featuring two unicorn bookends in tackles Lane Johnson and Jordan Mailata — the Eagles use a run-heavy approach with Saquon Barkley to dictate the tempo of the game.
ESPN Analytics projection: Eagles by 7.4 (68.7% chance to win)

Eric Moody: The defending Super Bowl champion Eagles deserve to be favored, but this spread feels inflated after the Micah Parsons trade pushed the line from -6.5 to -7.5, with it eventually reaching -8.5. The loss of Parsons is significant, but he didn't