May 14, 2025 - 23:19
By espn.com

2025 NFL schedule release - Betting odds for every Week 1 game - ESPN

The complete 2025 NFL schedule has been released, and odds are already available for Week 1.

The Philadelphia Eagles will begin their Super Bowl title defense against the Dallas Cowboys in the NFL's season opener on Thursday, Sept. 4.

The Eagles opened as a touchdown favorite at ESPN BET, but it's another NFC East team that has the largest spread of the Week 1 slate. The Washington Commanders opened as a 7.5-point favorite against the New York Giants.

The highest points total in Week 1 is in the Sunday night matchup between the Baltimore Ravens and Buffalo Bills. That number is 51.5, and the Bills opened as 1.5-point favorites at home.

Eleven games have spreads of a field goal or less.

Here's a look at the opening odds for every Week 1 game, as well as other highlights on the schedule that already have spreads.

Odds as of publication time. For most current odds, visit ESPN BET.

The defending Super Bowl champion Philadelphia Eagles will open the regular season against the Dallas Cowboys on Sept. 4.

Dallas Cowboys at Philadelphia Eagles (-7)
8:20 p.m. ET on NBC, Lincoln Financial Field, Philadelphia

Money line: Eagles -300, Cowboys +250
Total: 46.5 points

Kansas City Chiefs (-2.5) vs. Los Angeles Chargers
8 p.m. ET on YouTube, Corinthians Arena, São Paulo, Brazil

Money line: Chiefs -155, Chargers +135
Total: 44.5 points

New York Giants at Washington Commanders (-7.5)
1 p.m. ET, Northwest Stadium, Landover, Md.

Money line: Commanders -400, Giants +300
Total: 45.5 points

Tampa Bay Buccaneers (-1.5) at Atlanta Falcons
1 p.m. ET, Mercedes-Benz Stadium, Atlanta

Money line: Buccaneers -135, Falcons +115
Total: 48.5 points