2025-26 NBA Playoff Odds: Spreads, Lines for Second-Round Series

Now the NBA playoffs are in the swing of things.

Let's check out the odds for the second round of the playoffs, at DraftKings Sportsbook as of May 6.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports .

EAST SECOND ROUND

No. 4 CLEVELAND (+175) vs. No. 1 DETROIT (-210) 
DET leads 1-0

GAME 2 — CLE @ DET (May 7)

Spread: Pistons -3.5
Moneyline: Pistons -162, Cavs +136
O/U: 215.5

What to know: After trailing by as many as 17 in the second quarter of Game 1, Cleveland clawed its way back to tie the game at 93 late in the fourth. But Detroit showed its grit, ending the night on a 18-8 run to take a 1-0 lead. Everything about Game 1 pointed to this series being a slugfest.

No. 7 PHILADELPHIA (+350) vs. No. 3 NEW YORK (-450)
NYK leads 1-0

GAME 2 — PHI @ NYK (May 6)

Spread: Knicks -6.5
Moneyline: Knicks -270, 76ers +220
O/U: 215.5

What to know: Game 1 was all New York, all the time. The Knicks led by eight after the first quarter, 23 at half, 31 at the end of the third and ended the night with a 39-point victory. Jalen Brunson led the way, scoring 35 on 12-for-18 shooting, and as a team, the Knicks shot 63% from the field and 51% from 3. That'll get it done in the playoffs. Can N.Y. keep up its hot shooting in Game 2?

WEST SECOND ROUND

No. 4 LOS ANGELES (+1200) vs. No. 1 OKLAHOMA CITY (-3000)
OKC leads 1-0

GAME 2 — LAL @ OKC (May 7)

Spread: Thunder -15.5
Moneyline: Thunder -1000, Lakers +650
O/U: 210.5

What to know: If Game 1 was any indication, it appears that without Luka Dončić, the Lakers just don't have the firepower to compete with the Thunder. OKC outscored L.A. in every