2025-26 Men's March Madness odds: Premier Programs Vying at the Top

As every college football season creeps toward its end, a new college basketball season begins. 

Could the Florida Gators repeat? Will Purdue finally find its way to the top? Or can the Duke Blue Devils, with the top-ranked incoming recruiting class, emerge as champs?

Here’s a look at the odds from DraftKings Sportsbook as of Nov. 10.

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2025-26 Men's NCAA Tournament winner 

Houston: +1000 (bet $10 to win $110 total)
Purdue: +1100 (bet $10 to win $120 total)
Duke: +1200 (bet $10 to win $130 total)
UConn: +1300 (bet $10 to win $140 total)
Kentucky: +1300 (bet $10 to win $140 total)
Michigan: +1400 (bet $10 to win $150 total)
St. John's: +1600 (bet $10 to win $170 total)
Florida: +1800 (bet $10 to win $190 total)
BYU: +1800 (bet $10 to win $190 total)
Louisville: +2200 (bet $10 to win $230 total)
Texas Tech: +2200 (bet $10 to win $230 total)
Kansas: +2500 (bet $10 to win $260 total)
Arkansas: +2500 (bet $10 to win $260 total)
Illinois: +2500 (bet $10 to win $260 total)
Arkansas: +2500 (bet $10 to win $260 total)
Arizona: +3000 (bet $10 to win $310 total)
Alabama: +3000 (bet $10 to win $310 total)

Here's what to know about the NCAA college hoops title oddsboard:

The Favorites: Early in the season, it's crowded atop the oddsboard, with six teams at +1400 or shorter, led by Houston at +1000 and Purdue at +1100. The Cougars entered last year's tournament as the top seed in the Midwest Region, and fell to Florida — the West Region's top seed — in the national title game last season. Houston is currently the No. 2 team in the country, with wins over Lehigh and