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Tadhg Furlong, Cian Healy and Jamison Gibson-Park will all miss Ireland's crunch Six Nations game with France on Saturday but skipper Johnny Sexton is expected to be available.
By Saturday evening, we'll have an early idea of how well Ireland can deal with the target on their backs.
Ireland's preparations for Saturday's Guinness Six Nations opener against Wales have hit a major bump, after Tadhg Furlong was ruled out at the last minute.
Johnny Sexton has recovered from a facial injury and will captain Ireland from flyhalf but prop Tadhg Furlong has been ruled out of their Six Nations opener against Wales in Cardiff on Saturday.
Some players would have been content to make 14 appearances in the Six Nations. This weekend, Johnny Sexton will lead Ireland out for his 14th season in the championship.
Ireland must learn to embrace the expectation and scrutiny that comes with being the top ranked rugby team in the world, experienced forward Tadhg Beirne said on Tuesday.
There's a world in which Tadhg Beirne could have been playing against Ireland this Saturday, rather than for them.
The latest Six Nations campaign has crept up on us, and Cardiff will be the venue as Ireland try and pick up where they left off in the Autumn internationals.