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Connacht make six changes for their daunting BKT United Rugby Championship trip to Pretoria to take on the Bulls on Saturday [live on RTÉ2 and RTÉ Player] as Pete Wilkins hands a debut to number eight Sean Jansen.
Peter O'Mahony and Tadhg Beirne both return among four changes for Munster, ahead of the province's BKT United Rugby Championship meeting with the Stormers on Saturday.
Munster's Seán O'Brien says he has a new appreciation for his career after his brother's injury-enforced retirement.
Leinster will welcome back a number of their Ireland internationals for Sunday's clash with the Dragons but the World Cup contingent will be assessed on a case-by-case basis.
Connacht will be without versatile forward Josh Murphy for the upcoming season, with the 28-year-old taking a year out of the professional game to further his medical studies.
With the dust settling on an incredible season for Irish rugby, which saw the national team win the Grand Slam and Munster bridge a 12-year wait for silverware, Leinster will be somewhere in post-mortem mode following their Champions Cup final loss.
Leinster club captain Johnny Sexton reportedly swore at South African referee Jaco Peyper and his match officials after the Irish giants were beaten by La Rochelle in the Champions Cup final.
European Professional Club Rugby (EPCR) officials have launched an investigation into an alleged half-time tunnel bust-up during Saturday's Champions Cup final between Leinster and La Rochelle at Dublin's Aviva Stadium.