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Ireland are set to hand first caps to four players after coach Andy Farrell named his side to face Japan in their Nations Championship clash in Newcastle, Australia, on Saturday, including a start for number eight Sean Jansen.
Ireland captain Caelan Doris and winger Tommy O'Brien will miss Ireland's Nations Championship games in July.
James Lowe is set to make his 100th appearance for Leinster as he is named to start in their URC quarter-final against the Lions at the Aviva Stadium.
Cian Prendergast led from the front as Connacht booked a place in the URC knockout stages when they made the most of what they created to make it eight wins from their last nine league games to advance to the quarter-finals.
Connacht have picked up a crucial bonus-point 26-19 win at Ulster to boost their play-offs hopes in the United Rugby Championship
Sean Jansen scored two tries as Connacht claimed a 31-14 United Rugby Championship victory over Scarlets.
Ulster held off a rousing second-half fightback from Connacht to close out a hard-fought 29-24 win at Dexcom Stadium.
The Ospreys launched their European Challenge Cup campaign with a remarkable 24-21 comeback victory over Connacht at the Brewery Field, overcoming a dire first half and a 21-point deficit to claim a dramatic bonus-point win.