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Neil Powell made numerous changes to his Sharks team as Lukhanyo Am starts at No 13 and Siya Kolisi drops to the reserves in a team led by Phendulani "Phepsi" Buthelezi for the Lions visit to Kings Park on Friday.
The Sharks are boosted by the return of Springbok captain Siya Kolisi and star lock Eben Etzebeth for their Champions Cup opener against England's Harlequins in Durban on Saturday.
The Ospreys have been forced into a late change ahead of their United Rugby Championship clash with the Sharks later today after Rhys Webb was ruled out by illness.
The Sharks welcome back a number of Springboks for Friday night's URC clash against Wlesh side Ospreys in Durban.
The Sharks will be without their current Springbok heavyweights Eben Etzebeth, Siya Kolisi, Bongi Mbonambi and Makazole Mapimpi for Sunday's clash against the Bulls in the United Rugby Championship (URC).
Springbok lock Eben Etzebeth will make his debut for the Sharks after being included in the starting XV to tackle Scottish outfit Glasgow Warriors in Durban on Saturday.
Sharks coach Sean Everitt said a win against Irish giants Leinster in Dublin on Saturday will be a massive boost for them in their United Rugby Championship campaign.