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Scrumhalf Rhys Webb will make his first start for Wales this year in their Six Nations clash with Italy on Saturday, while flyhalf Dan Biggar has been ruled out with a back injury as coach Warren Gatland goes for broke in the crunch game in Rome.
Harlequins fly-half Tommy Allan will start at full-back for Italy in Saturday's Guinness Six Nations clash against Wales.
The biggest fixture of the Welsh international calendar — Wales v England — is finally here, after plenty of talk and doubts over whether it would go ahead.
Wales' players have returned to training full of fight and eager to reverse their recent poor run after a torrid week according to coach Warren Gatland as they prepare to face England in the Six Nations in Cardiff on Saturday.
Wales have wielded the axe with nine changes to their side for the Six Nations showdown with England on Saturday, including a start for Owen Williams ahead of Dan Biggar at flyhalf as coach Warren Gatland desperately seeks a winning formula.
Fly-half Dan Biggar and centre George North have been left out of the Wales team for Saturday's Guinness Six Nations clash against England in Cardiff.
Experienced lock Alun Wyn Jones has been left out of the Wales match-day 23 to face Scotland in their Six Nations clash at Murrayfield on Saturday as head coach Warren Gatland says they are "looking to the future".
Wales boss Warren Gatland has left out three British and Irish Lions – Alun Wyn Jones, Justin Tipuric and Taulupe Faletau – from the starting line-up for Saturday's Guinness Six Nations clash against Scotland.