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Harry Byrne's hopes of earning an Ireland recall have taken a blow, with the out-half ruled out of Saturday's Investec Champions Cup Pool 4 meeting with Stade Francais (live on RTÉ2 and RTÉ Player) due to an ankle injury.
Peter O'Mahony will make his return from injury for Munster in Toulon tomorrow with the former captain named in the back row for the Investec Champions Cup Pool 3 clash.
Following the retirement of Johnny Sexton and a glut of high profile injuries, RTÉ rugby analyst Bernard Jackman admitted to some "worry" about Ireland's prospects ahead of what could be a transitional Six Nations campaign.
Monday was a tough day for Irish rugby wingers.
DUBLIN :Ireland suffered a double injury blow on Monday when backs Mack Hansen and Jimmy O'Brien were ruled out of their Six Nations title defence through long-term injuries.
Ireland boss Andy Farrell has been hit with another injury blow after Leinster wing Jimmy O'Brien was ruled out for "a number of months" with a neck injury.
Ireland fell at a familiar fence at the World Cup again, going out 28-24 to New Zealand.
Ex-New Zealand captain Richie McCaw said his former side have to start well against Ireland in Saturday's Rugby World Cup quarter-final if they hope to upset the odds.