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He had the chance to put Mauricio Pochettino's side ahead in the first leg of their Champions League last 16 clash on Tuesday evening, but Courtois got down low to save his spot kick.
Marco Asensio scored the only goal as Real Madrid beat Granada to go six points clear at the top of La Liga.
:Real Madrid's Karim Benzema will miss Thursday's Copa del Rey quarter-final against Athletic Bilbao as he is still recovering from a leg muscle injury, the club announced on Wednesday.