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Tadhg Furlong, Cian Healy and Jamison Gibson-Park will all miss Ireland's crunch Six Nations game with France on Saturday but skipper Johnny Sexton is expected to be available.
Ireland have been forced to make a late change ahead of their Six Nations opener with Jamison Gibson-Park ruled out through injury, with Conor Murray stepping up to the starting XV.
DUBLIN : Ireland named a near full-strength squad for the Six Nations on Thursday, with just one uncapped player among the 37 selected and captain Johnny Sexton included as expected as he bids to return to fitness for the Feb. 4 opener in Wales.
Hugo Keenan will make his 50th appearance for Leinster when they face Gloucester at Kingsholm in Saturday's Heineken Champions Cup tie (kick-off 1pm).
Munster head coach Graham Rowntree has sprung a major surprise, with Conor Murray dropped from the matchday squad for Saturday's crucial Heineken Champions Cup Round 3 game against Northampton Saints (live on RTÉ2 and RTÉ Player).
Munster assistant Denis Leamy has ruled out a move for Malcolm Marx, ending speculation the Springbok could be joining the province after the World Cup.
Munster head coach Graham Rowntree has rested Peter O'Mahony, Tadhg Beirne, Joey Carbery and Craig Casey for Sunday's meeting with Ulster at Kingspan Stadium, while the hosts have been boosted by the return of several injured players for the New Year's Day derby.
Craig Casey says Munster can't dwell on their St Stephen's Day defeat to Leinster, as they prepare for another crucial Interpro on Sunday against Ulster.