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Munster head coach Graham Rowntree has rested Peter O'Mahony, Tadhg Beirne, Joey Carbery and Craig Casey for Sunday's meeting with Ulster at Kingspan Stadium, while the hosts have been boosted by the return of several injured players for the New Year's Day derby.
John Ryan will make his 200th appearance for Munster when they visit Edinburgh in the BKT United Rugby Championshipon Friday while Simon Zebo is handed his first league start since September.
Munster have named a youthful looking squad for Thursday's historic match against a South Africa XV at Páirc Úi Chaoimh.
Alex Kendellen grew up in the shadow of Páirc Uí Chaoimh but he thought his chances of playing at the iconic venue were over when he swapped the round ball for an oval one.
Munster have to be braced for a Connacht backlash in this Friday's Interpro against Connacht in Galway, according to assistant coach Mike Prendergast.
Munster Rugby have confirmed contract extensions for five players, including Ireland internationals Craig Casey, Shane Daly and Mike Haley.
Munster say Peter O'Mahony will return to training later this week, with the captain nursing an ankle injury sustained in Sunday's defeat to Dragons in Newport.
The United Rugby Championship season gets under way for the Welsh teams as Cardiff host Munster at the Arms Park.