Aston Villa's bid to finish in the Premier League's top four was rocked by a 1-0 defeat at Brighton, while Chelsea thrashed West Ham 5-0 to keep alive their hopes of European qualification on Sunday.
A Villa win combined with a Tottenham loss at Liverpool in Sunday's late game would have sealed a Champions League place for Unai Emery's side.
But Villa were unable to fulfil their part of that equation as Joao Pedro's 87th minute goal condemned them to a second painful defeat in four days.
Ending Brighton's six-match winless run, Pedro headed in the rebound after Robin Olsen saved his penalty, which had been awarded for Ezri Konsa's foul on Simon Adingra.
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