Tottenham Hotspur a 1-0 home victory over Wolverhampton Wanderers that sent them to the top of the table. Tottenham were outplayed in the first half but were a different proposition after the interval, with Kane pouncing in the 64th minute to score his 185th Premier League goal.
No other player has scored more goals for a single club in the Premier League era, with England skipper Kane moving clear of Sergio Aguero's tally for Manchester City.
Wolves, who are now winless in their last 10 Premier League games, had 12 goal attempts to Tottenham's one in the first half but were unable to make their superiority count.
Tottenham then found some extra gears to seize control, with Kane and Son Heung-min both being denied by the woodwork before Kane headed in from a corner flicked on by Ivan Perisic.