The Australian was in complaint mode from the start, lamenting the distraction of flickering LED lights on an advertising board and demanding a fix.
World number 28 Kyrgios, after a standout summer which included the Washington title this month, could not find his best game in crashing out to 11th seed Fritz after only 50 minutes.
The Aussie had beaten his last five American opponents and stood 15-2 since his surprise Wimbledon final against Novak Djokovic.
But after confessing that he is counting the days until he can return home after the US Open, Kyrgios seemed uninterested in the job on court.
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