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Raheem Mostert grabbed a pair of rushing touchdowns as the Miami Dolphins held off AFC East rivals the New England Patriots 24-17 for a second win on the road to start the season.
D'Andre Swift starred for the Philadelphia Eagles to secure their second win in two games, beating the Minnesota Vikings 34-28 at Lincoln Financial Field.
Four-time NFL MVP Aaron Rodgers will miss the rest of the season after tearing his Achilles tendon in his first league game for the New York Jets.
Green Bay Packers punter Dan Whelan became the Irish-born player to feature in an NFL game since 1985 when he made a highly encouraging competitive debut in his side's 38-20 victory over the Chicago Bears at Soldier Field.
David Montgomery's eight-yard touchdown run with 7:06 left on Thursday night propelled the visiting Detroit Lions to a season-opening, 21-20 win over the Super Bowl champion Kansas City Chiefs in the NFL's season-opening game.
Irish-born Dan Whelan has been included on the Green Bay Packers' 53-man roster for the upcoming NFL season.
Three years ago, almost 40,000 US visitors had made arrangements to come to Dublin for the season-opening college football game between Notre Dame's 'Fighting Irish' and Navy at the Aviva Stadium.