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Brighton dumped FA Cup holders Liverpool out of the competition on Sunday as Hollywood star and Wrexham co-owner Ryan Reynolds saw his non-league side denied a dramatic win by Sheffield United in a six-goal thriller.
Giovanni Simeone scored a late winner as Napoli continued their march at the top of Serie A with a 2-1 win over Roma.
Arsenal and Manchester City recorded big victories as they cruised through to the fifth round of the Women's FA Cup against lower-league opposition.
Kaizer Chiefs ended a three-match losing streak in the South African Premiership by defeating Royal AM 2-0 on Sunday.
National League leaders Wrexham were denied another FA Cup giant-killing as a stoppage-time equaliser from Republic of Ireland defender John Egan ensured 10-man Championship high-flyers Sheffield United forced a replay after an absorbing 3-3 draw.
Brighton boss Roberto De Zerbi insists the club must keep wantaway midfielder Moises Caicedo if they are to maintain their bid for a place in Europe.
Aaron Mooy scored one goal and set up another as Celtic beat Dundee United 2-0 to restore their nine-point lead in the cinch Premiership.
Republic of Ireland youngster Evan Ferguson went off with an injury late in the game as Brighton knocked Liverpool out of the FA Cup thanks to Kaoru Mitoma's excellent late winner.